Abstract

Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucoma were analyzed regarding their vertical cup-to-disc-ratio (CDR). Vertical CDR, disc area, cup volume, rim volume, and maximum cup depth were assessed with both devices by one examiner. Mean bias and limits of agreement (95% CI) were obtained using scatter plots and Bland-Altman analysis. Results. Overall vertical CDR comparison between HRT III and Kowa nonmyd WX3D measurements showed a mean difference (limits of agreement) of −0.06 (−0.36 to 0.24). For the CDR < 0.5 group (n = 24) mean difference in vertical CDR was −0.14 (−0.34 to 0.06) and for the CDR ≥ 0.5 group (n = 16) 0.06 (−0.21 to 0.34). Conclusion. This study showed a good agreement between Kowa nonmyd WX3D and HRT III with regard to widely used optic nerve head parameters in patients with glaucomatous optic neuropathy. However, data from Kowa nonmyd WX3D exhibited the tendency to measure larger CDR values than HRT III in the group with CDR < 0.5 group and lower CDR values in the group with CDR ≥ 0.5.

Highlights

  • Glaucoma is one of the leading causes for irreversible blindness in western nations [1]

  • The agreement between morphometric optic nerve head parameters assessed with Heidelberg Retina Tomograph (HRT) III and Kowa nonmyd WX3D was analyzed using mean differences and limits of agreement

  • This study evaluated the agreement of optic nerve head parameters obtained by Kowa nonmyd WX3D and HRT III with regard to the vertical CDR in glaucomatous patients for the first time

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Summary

Introduction

Glaucoma is one of the leading causes for irreversible blindness in western nations [1]. Morphometric optic nerve head parameters like cup-to-disc-ratio (CDR), cup and rim volume, and mean or maximum cup depth are surrogates for glaucomatous optic neuropathy. These parameters are significantly correlated with visual field indices such as mean deviation (MD) and pattern standard deviation (PSD) [2, 3]. While morphometric optic nerve head analysis is useful for detecting early structural changes [4], perimetry is used for monitoring functional changes [5]. Morphometric examinations are an objective way to monitor both manifestation and progression of optic neuropathy by detecting changes in optic nerve head parameters in patients with primary open angle glaucoma and ocular hypertension [7, 8]

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