Morphometric indices of secretory epithelium of main prostate glands in people 13-88 years old

Abstract

The aim of the study was to study the age-related changes in the epithelium of the end pieces of the prostate main glands, in all its structural lobules in the age range from adolescence late adulthood age. Materials and methods. Histological, morphometric methods were used to study the secretory epithelial cells of the end pieces of the main glands on prostate preparations of 77 men aged 13-88 years, on autopsy material. The histological sections were stained with hematoxylin and eosin, studied using a Leica DM-2000 microscope with a video projection system, using the Leica "LAS V3.6" application morphometric program. Shape and sizes of the secretory epithelial cells of the end pieces of the prostate main glands in pairs of anteromedial, superomedial, inferoposterior, inferolateral structural lobes (zones) were determined. To evaluate the results obtained, nonparametric methods of mathematical statistics were used (Wilcoxon W-test for comparison of two independent samples, Kraskel-Wallis H-test for multiple comparisons, Dann's test with Bonferroni amendment). Results. The differences of the morphometric parameters of secretory epithelial cells in pairs of anteromedial, superomedial, inferoposterior, inferolateral structural lobes (zones) of the human prostate within each of the studied age periods and changes of these parameters according to the age periods from adolescents to late adulthood age were detected. Conclusion. The development and growth of secretory epithelium in all structural lobules of the prostate were observed in the age interval 13-35 years, and the atrophic processes begin at the age of 36, but these changes occur asynchronously, both within one end piece of the gland and in different structural lobules. The changes of the epithelium in the prostate does not always correspond to the calendar age of men.