Abstract
Due to the growing incidence of cancer in the world, it is becoming more relevant to study the indicators of secondary changes in blood in malignancies to use them as diagnostic and prognostic markers. The objective of the work is to conduct a morphometric analysis of peripheral blood erythrocytes in patients with iron deficiency anemia (IDA) and malignant anemia in colorectal cancer to identify specific changes and use them in a differential diagnostic practice. As the study material blood of 110 patients (58 men and 52 women) was taken. Among them 53 patients (31 women and 22 men) with IDA were examined, they formed the first (I) observation group and 57 patients (36 men and 21 women) with colorectal cancer, where the course of the underlying disease was burdened by malignant anemia second (II) observation group. The age of the patients under the survey is from 22 to 69 years. All patients were examined before any treatment was prescribed. The control group consisted of 50 healthy primary donors. Results. The data on the clinical significance of laboratory determination of morphometric changes in peripheral blood erythrocytes is highlighted in this paper. Differential-diagnostic and prognostic value of morphometric changes of erythrocytes in peripheral blood with iron deficiency anemia and anemia of malignancies is discussed. Indicators of morphometric characteristics of erythrocytes can be used in the differential diagnosis of anemia.
Highlights
Colorectal cancer takes a leading place in the structure of cancer incidence in Ukraine – the second one among men and the third one among women, in the structure of mortality, it takes the second place in both men and women
The objective of the work is to conduct a morphometric analysis of peripheral blood erythrocytes in patients with iron deficiency anemia (IDA) and malignant anemia in colorectal cancer to identify specific changes and use them in a differential diagnostic practice
Among them 53 patients (31 women and 22 men) with IDA were examined, they formed the first (I) observation group and 57 patients (36 men and 21 women) with colorectal cancer, where the course of the underlying disease was burdened by malignant anemia second (II) observation group
Summary
Colorectal cancer takes a leading place in the structure of cancer incidence in Ukraine – the second one among men and the third one among women, in the structure of mortality, it takes the second place in both men and women. Dynamic models of colorectal cancer incidence in Ukraine for the last 20 years show a steady increase in both male and female population, with the predominance in men. Significant shortcomings in the prevention, diagnosis and treatment of patients with colorectal cancer lead to the fact that 27,6 – 33,3 % of them died within one year since the time of diagnosis, and in some areas, this rate exceeds 40 %. Survival of persons with colorectal cancer directly depends on the timeliness of cancer detection, the 5-year relative survival rate of patients with early stages of the cancer is 8-10 times higher than of those with advanced stages (Fedorenko et al, 2019)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
