Morphometric analysis of the sella turcica in Northeastern Brazil

Pablo Mariz De Oliveira,Amanda Do Nascimento Oliveira E Carneiro,Desiré Dominique Diniz De Magalhães,Leticia Leite Cavalcante,André De Braga Sá De Oliveira,Fábio Antônio Serra De Lima Júnior,Daniel Dantas Da Silva

doi:10.5327/1516-3180.509

Abstract

Introduction: The sella turcica is a structure of the median region of the sphenoid bone. Variations in its morphology are relevant as it is a region subjected to several surgical procedures, mainly related to the pituitary gland. Objective: To analyze the morphology of the sella turcica and its sexual dimorphism in Northeastern Brazil. Methods: Fifteen human skulls from the Federal University of Paraíba (UFPB) were used. The qualitative analysis was performed by classifying the shape of the sella turcica into three types: U, J and flattened. Morphometric data was collected and statistically analyzed to evaluate the relationship between sella morphometry and gender, and between sella and skull measurements. Values of p< 0.05) in the sella turcica length (STL) and skull length (SL), with male skulls being larger in both cases. The other linear measurements didn’t show differences between the sexes (p>0.05). There was a positive linear correlation between STL and SL, and a negative linear correlation between sella turcica width (STW) and sella turcica height (STH) and between STH and bitemporal width (BTW). Conclusion: The results point to important differences in the morphometric parameters evaluated with original findings for this population. Knowledge of the morphology of the sella is essential to plan safer surgical approaches in the pituitary gland or related anatomical structures.

Highlights

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A

Summary

Introduction

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones

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