Morphology of regenerated bone tissue under effect of Easygraft and amorphous calcium phosphate implants.

Abstract

Background. The theoretical basis of osteoplasty, fully supported by clinical observations, is that violations occur in periodontitis of correlation between tooth and the surrounding tissues, including the microcirculation. However, multifaceted morphological and clinical analysis of effectiveness of the material held EasyGraft was not. Objective. The aim was experimental evaluation of tissue alterations in bone implant materials Easy-Graft® and tricalcium phosphate®. Methods. The comparative analysis of quantitative morphological estimation of regenerative processes in osteal tissue in model of osteal defect is carried out at implantation of material EasyGraft and amor­p­hous calcium phosphate. Results . Implantation of amorphous calcium phosphate on the 7th day of observation defined system defect initial signs of degradation and sprouting of blood vessels. Intervals around the particles of the material have been filled by fibrose tissue. Among the spongy bone substance occurred active formation of new bone tissue. After 15 days of observation of the implanted material adjustment processes were more pronounced: define complex regenerate formed by osteogenic tissue with inclusions of large volume graft particles. On the 30th day of the experiment, all of the defect area was riddled with large bony trabeculae, actively carry out the process of compaction of bone and subsequent biological degradation of the implant. After 60 days, the fragments were subjected defragmentation implant and bone substitution. In the inter-trabecular spaces formed sections filled with yellow bone marrow. Between trabecular bone, and substituted defect area boundary is not observed. Conclusion. EasyGraft and amorphous calcium phosphate undergo resorbtion and thus optimize bone regeneration. Regeneration is accompanied by decreased specific area of the particles implanted and increased integration index and specific density of trabeculae within the reaction zone. Highest intensity of these processes observed in the period from 15th fill the 30th day after implantation.