Abstract
Purpose: this study morphological changes the exorbital lacrimal glands at experimental impact on an organ of vision of high-intensity light. Material and methods. White not purebred rats males (n = 40) were subjected to continuous influence of light intensity by 3500 lx within 1, 7, 14 and 30 days, the control group (n = 10) contained in conditions of natural lighting (20 lx). Exorbital lacrimal glands fixed in formalin, embedded in paraffin wax, stained hematoxylin-eosine. By means of an oculary insert of Avtandilov counted specific volumes of output channels, an epithelium, stroma and vessels of exorbital lacrimal glands, defined an epitelio/stroma ratio. The analysis of data was carried out by methods of descriptive statistics with calculation of a median (Ме) and interquartile range (Q1 –Q3). For an assessment of distinctions used nonparametric criterion of Mann – Whitney. Results. In 1 days in response to high-intensity light influence there is a reflex strengthening of synthetic function of exorbital lacrimal glands. For the 7th days the first signs of violation of functioning with development of hydropic dystrophy in the lacrimacytes appear. By 14th days fibrous changes develop, in a glandular parenchyma harderization sites appear. For the 30th days the nuclear pycnosis of separate lacrimacit, accumulation of a lipofuscin in cytoplasm is observed. Conclusion. The obtained data allow to estimate in dynamics compensatory and adaptive reactions of lacrimal gland in response to high-intensity light influence from the moment of the beginning of their development before emergence of the first signs of a decompensation.
Highlights
Exorbital lacrimal glands fixed in formalin
In 1 days in response to high-intensity light influence there is a reflex strengthening of synthetic function of exorbital lacrimal glands
Ilinskich Nikolai N., DBSс, Рrofessor, Head of Department Biology and Genetics, Siberian State Medical University, Tomsk, Russian Federation
Summary
Для цитирования: Мустафина Л.Р., Журавлева А.Д., Логвинов С.В., Карпова М.Р., Ласукова Т.В., Суханова Г.А., Ильинских Н.Н. Морфология экзоорбитальных слезных желез беспородных белых крыс при высокоинтенсивном световом воздействии. Мустафина Л.Р.1, Журавлева А.Д.1, Логвинов С.В.1, Карпова М.Р.1, Ласукова Т.В.2, Суханова Г.А.1, Ильинских Н.Н.1. Цель: изучить морфологические изменения экзоорбитальных слезных желез при экспериментальном воздействии на орган зрения высокоинтенсивного света. Через 1 сут в ответ на высокоинтенсивное световое воздействие возникало рефлекторное усиление синтетической функции экзоорбитальной слезной железы. Морфология экзоорбитальных слезных желез беспородных белых крыс поверхности глазного яблока и прозрачность роговицы, защиту от инфекции, а также способствует заживлению ран при повреждениях [2]. Целью данного исследования явилось изучение морфологических изменений экзоорбитальных слезных желез при экспериментальном воздействии на орган зрения высокоинтенсивного света
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