Abstract
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Highlights
There is a tight structural relation and functional co-operation between the nervous, endocrine and immune systems
A similar “IL-1 phenomenon” like in Lurchers and staggerers exists in Purkinje cell degeneration mutants and to a lesser extent in reeler and wobbler mice, but was absent in the neurological mutants weaver, jimpy, and motor end plate disease (Kopmels et al 1990)
The above mentioned studies lead us to the hypothesis that the neuronal degeneration affecting the cerebellum in different mutant mice do not lead to the same immunological defect at the peripheral level
Summary
There is a tight structural relation and functional co-operation between the nervous, endocrine and immune systems. A dense network of soluble neuro-endocrine and immune mediators exists to ensure close interactions. These hormones, cytokines and neurotransmitters all interact through positive and negative feed-forward and feedback loops. Our observations confirm the idea of the tight cooperation of neuro-endocrine-immune structures and contribute to its better understanding, in the conditions of postnatally progressing neurodeficiency. To contribute to the explanation of these relations we used in our previous study “an experiment of the nature”, gross-brain malformation – anencephaly - which eliminates the central nervous system and the neuro-endocrine part of the homeostatic system (Slípka et al 1997; B e ranová 1994). The spontaneously aborted human foetuses without any external malformation and human anencephalic foetuses were compared with
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