Abstract

The yolk sac is the most representative organ of the first trimester of human pregnancy. Its disappearance at the end of the third month of gestation represents a turning point in human development in utero. The human yolk sac is an extremely small and fragile structure which makes its investigation difficult. However, during the past 50 years, several studies have demonstrated the complexity and importance of the yolk sac function in early pregnancy. This chapter is a brief review of the anatomy and the potential role of the human yolk sac in relation to embryonic and fetal development during the first 12 weeks of gestation.

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