Abstract
The standard method of the C3 H 10 T 1 2 CL8 cell transformation assay cannot adequately detect alkylating agents. A modification of the standard procedure as described by Bertram and Heidelberger using a large number of synchronized cells and high levels of toxicity was evaluated for transformation using several alkylating agents. By using this method, N-methyl- N'-nitro- N-nitrosoguanidine (MNNG), β-propiolactone (BPL), methyl methanesulfonate (MMS), methylnitrosourea (MNU) and 1,3-propane sultone (PS) transformed these cells. However, methyl iodide (M1) failed to induce any transformed foci.
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