Morphological traits according to BMI of LRP5 rs121908669 genotype carriers

Abstract

Descriptive diagnostic is a part of clinical diagnosis. It is not reliable, but it is prompt. Therefore, it is necessary to determine the phenotypes of the genotypes of carriers of LRP5G171R. This cross-sectional study was performed on 150 premenopausal and postmenopausal women with a mean age of 40 years. Body mass index (BMI) was calculated. To determine the genotypes of LRP5 rs121908669, a PCR-RFLP assay was performed and the results were confirmed by DNA sequencing. The likelihood test, chi-square test, binary logistic regression test and odds ratio test were used to determine the associations between BMI and the genotype of LRP5G171R. The likelihood test confirmed the relationship between BMI and LRP5G171R (ϰ2 =15.658, p=0.048). The results indicate that there are positive correlations between obese BMI and extremely obese BMI and between obese BMI and GG (ϰ2 =23.707, 14.013 p=0.000, 0.00). There was a negative correlation between normal BMI and GG (ϰ2 =19.675, p=0.000). There was a negative correlation between extremely obese BMI and CC (ϰ2 =12.466, p=0.000). There was a negative correlation between BMI and GC in obese individuals (ϰ2 =19.997, p=0.000). Finally, obesity and extreme obesity are positive factors. The carriers of the mutant LRP5G171R (GC, CC) will be protected from obesity, unlike carriers of the normal genotype (GG) which will suffer from obesity. This SNP can be added to NCBI as an SNP associated with obesity.