Abstract
The distal airways and neighboring regions of lungs from healthy (control) rats and from rats exposed to 15 ± 2 ppm NO 2 for 1, 2, and 7 days were dissected out and examined with the scanning electron microscope. The three types of bronchiolar epithelial cells were identified on the terminal bronchiolar surface of unexposed animals. Type I, Type II, and alveolar brush cells were identified in the alveolar duct regions. Morphological surface changes involved in the initial response to nitrogen dioxide (NO 2 included loss of cilia and increased uniformity of surface in the terminal bronchiole. Type I cells in the proximal alveolar duct region near the end of the terminal bronchiole were substantially replaced by microvilli-covered cells. Increases in the amount of debris and the number of macrophages were also evident in the response to the gas. Several specimens that had been examined in the scanning electron microscope were subsequently prepared for transmission electron microscopy.
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