Abstract
Background. Since NSAIDS have some detrimental side effects, studying new combinations of NDAIDS with other substances could provide a reduction of the dosage of the NSAID while retaining therapeutic effectiveness. Objective. To study the effect of Diclocor on the cartilage morphology in the course of collagen-induced arthritis in rats in comparison with sodium diclofenac and quercetin. Methods. Autoimmune arthritis was reproduced by subcutaneous injections of type II collagen ("Sigma-Aldrich", USA). Morphological studies were performed using standard light microscopy techniques. Results. After treatment with both Diclocor and diclofenac sodium no cartilage destruction was oberved and tissue hyperplasia was low. Some residual effects were observed in the synovial membranes in the Diclocor group, and in periarticular tissues – in the diclofenac sodium group. Under the action of quercetin, there was a sufficiently high level of hyperplastic processes and pannus formation in sinovium. Conclusion. Diclocor and diclofenac sodium express a profound normalizing effect, while Quercetin is less active.
Highlights
Since NSAIDS have some detrimental side effects, studying new combinations of NDAIDS with other substances could provide a reduction of the dosage of the NSAID while retaining therapeutic effectiveness
Autoimmune arthritis was reproduced by subcutaneous injections of type II collagen ("Sigma-Aldrich", USA)
Дослідження впливу Диклокору на перебіг колаген-індукованого артриту (КІА) проведено на 50 білих нелінійних щурах обох статей масою 180-200 г, що розподілялись на 5 дослідних груп по 10 тварин у кожній: 1 група – інтактний контроль; 2 група – контрольна патологія; 3 група – тварини, що отримували Диклокор у дозі 17,8 мг/кг; 4 група – тварини, що отримували кверцетин у дозі 11,0 мг/кг та 5 група – тварини, що отримували диклофенака натрія (ДН) у дозі 6,8 мг/кг
Summary
To study the effect of Diclocor on the cartilage morphology in the course of collagen-induced arthritis in rats in comparison with sodium diclofenac and quercetin. Диклокор У групі щурів з КІА під впливом Диклокору завершення патологічного процесу хрящовою деструкцією виявлено не було, що свідчить про запобігання розвитку деструктивнодистрофічних процесів в хрящовій тканині.
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