Abstract
We studied the progressive histopathological changes in the colons and livers of hamsters subjected to weekly subcutaneous injections of 1,2-dimethylhydrazine (DMH) for 21 weeks by sacrificing animals on a weekly basis. After 15 injections, all remaining animals ( N = 17) displayed neoplastic lesions of the colon. Of the 17 animals, ten exhibited adenocarcinomas in situ. Of the remaining seven which showed invasive adenocarcinomas of the colon, five animals also revealed metastatic lesions in the liver. Tumor progression followed the course of colonic enteritis (5 weeks), focal atypias (7 weeks), glandular dysplasias (10–14 weeks), carcinomas in situ (15 weeks), and invasive adenocarcinomas (17 weeks). Ultrastructural features of both tumors and normal hamster colon were studied. Alterations in nuclear contour, size of intercellular spaces, and shape and density of luminal microvilli were noted. The toxic effect of DMH on the liver in these animals was pronounced and was associated with certain progressive morphological changes described herein.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
