MORPHOLOGICAL SPECTRUM OF INTRACRANIAL SPACE OCCUPYING LESION AT TERTIARY CARE HOSPITAL-A CLINICOPATHOLOGICAL STUDY

Abstract

Introduction: The annual incidence of CNS tumors ranges from 10 to 17 per 1,00,000 persons for intracranial tumors, [1] the majority of these are primary tumors. An “Intra-cranial space occupying lesion” (ICSOL)is dened as a mass lesion in the cranial cavity with a diverse etiology like benign or malignant neoplasm, inammatory or parasitic lesion, hematoma, or arterio-venous malformation.[3] Many non-neoplastic CNS lesions can clinically & radiologically simulate brain tumors. In such cases, histopathological [5] examination (HPE) can be helpful in differentiating between neoplastic and non-neoplastic etiologies. Aims and Objectives: This studywas undertaken to analyse theincidence and frequency of intracranial space occupying lesions, age and sex wise distribution, associated clinical symptoms and histopathological spectrum. Intracranial space occupying lesion biopsi Materials and Methods: es of 108 cases received indepartment of pathology, B.J. Medical College, Ahmedabad, during the period of March 2021 to August 2021. All specimens were preserved in 10% formalin and allowed to x for 24 hours, parafn embedded sections of 5 microns were cut. The hematoxylin and eosin stained sections of the CNS lesions were studied. One Hundred and Eight cases of Intracranial Spac Result: e Occupying lesions were studied, of which 8 (7.4%) cases were non neoplastic with 6 (75%) being cystic lesions and 2 (25%) were cerebral abscess. The neoplastic lesions comprised of 100 (92.6%) cases, which included 99 (99%) primary and 1 (1%) metastatic lesions. The most frequent type of CNS tumor was astrocytoma and oligodendroglioma (23 cases, 23%) followed by Meningioma (18 cases, 18%), pituitary adenoma (17 cases, 17%), Ependymoma(13 cases, 13 %) and metastatic tumor (1 case, 1%). The surgical pathologist plays an importa Conclusion: nt role in accurate diagnosis of various Intra [3] Cranial Space Occupying lesions which will be of immense help for patient prognosis and treatment.