Abstract
Cellulose has been widely used in the biomedical field. In this study, novel cellulose aerogels were firstly prepared in a NaOH-based solvent system by a facile casting method. Then amoxicillin was successfully loaded into cellulose aerogels with different loadings. The morphology and structure of the cellulose aerogels were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The drug release and antibacterial activities were also evaluated. The drug release results showed that cellulose aerogels have controlled amoxicillin release performance. In vitro antibacterial assay demonstrated that the cellulose aerogels exhibited excellent antibacterial activity with the amoxicillin dose-dependent activity. Therefore, the developed cellulose aerogels display controlled release behavior and efficient antibacterial performance, thus confirming their potential for biomedical applications.
Highlights
Aerogels are three-dimensional network materials derived from gel networks by replacing the liquid medium with gas [1]
When the formed cellulose solution was immersed into a de-ionized water, NaOH molecules bonded on the –OH groups of cellulose diffused into water, so the new hydrogen bonds were regenerated
The rearrangement of the hydrogen bonds leads to the regeneration of cellulose
Summary
Aerogels are three-dimensional network materials derived from gel networks by replacing the liquid medium with gas [1]. They show great promise for using as supporting substrate, owing to their high surface area, low density, high specific surface area, recyclability, biodegradability, low cost and aqueous stability [2]. Cellulose is the most abundant natural renewable polymer on Earth. It is a linear polysaccharide formed by β-1-4-linked D-glucopyranose repeating units [7]. Cellulose has potential in various applications, such as the paper industry, medicine and electronics industry, packaging materials, energy areas, hygiene and biomedical industries, and the cosmetic and food industries [9,10]. Silver nanoparticles have been reported to load into cellulose by many researchers to endow it with antibacterial and antifungal properties [12,13,14,15]
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