Abstract
We studied macro and microscopic changes in kidney tissue against the background of polypharmacy when modeling renal pathology. It has been shown that the simultaneous use of more than 5 drugs has a nephrotoxic effect on the proximal renal tubules. On macroscopic examination, the kidneys were bean-shaped, the capsule was smooth; with the help of a magnifying glass, it was smooth, shiny, without visible differences. Microscopically, in the kidney tissue in the study group, some structural differences were revealed, the nature and severity of which depended on the type of active drug. In the glomerular apparatus of the kidneys of rats, focal infiltration of mesangial cells was noted. Moreover, in the direct tubules of the kidney apparatus, remarkable changes were not revealed. Thus, it was concluded that tubular damage leads to impaired tubular reabsorption, proteinuria, the morphological criteria of steatosis, and dysproteinosis of varying degrees.
Highlights
As the central organ of the excretory system, the kidney performs an essential function of maintaining the constancy of the internal environment of the body and takes part in its regulatory mechanisms
The animals were dissected; for morphology, one piece of tissue was taken from the kidneys, fixed in 10% formalin, standard paraffin wiring was carried out and embedded in paraffin. 5-7 mm thick sections were prepared from the paraffin blocks
In the kidney tissue in the study group, some structural differences were revealed, the nature and severity of which depended on the type of active drug
Summary
As the central organ of the excretory system, the kidney performs an essential function of maintaining the constancy of the internal environment of the body and takes part in its regulatory mechanisms. The complex functions of the permanent human kidney are provided by the interconnected and interdependent function of the generations of nephrons and collecting ducts, which have features of the structure of the renal tubules, their length, depth in the cortex, and medulla, relative position, blood supply. The USA Journals Volume 03 Issue 10-2021. Relationships of the nephrons in conjunction with the collecting ducts provide the overall excretory function of the kidney. Purpose of the study: To study the macroscopic and microscopic changes in the parameters of the renal nephron when modeling renal pathology
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