Abstract
The goal of the work was to study changes of structural and cytochemical organization of activated hippocampal astrocytes in the rat exposed to transient global ischemia of the brain. Intermediate filament proteins immunocytochemistry revealed functional activation of astrocytes of dorsal hippocampus 7 days following the ischemia, which was manifested as changes of size and shape of the cells and processes and accumulation of intermediate filament proteins GFAP and nestin. This is accompanied by formation of two populations of activated astrocytes: GFAP-positive astrocytes, which are more abundant and nestin-positive astrocytes distributed predominantly in the area of massive loss of neural cells. The obtained data suggest that astrocytes activated post-ischemically obtain properties typical for immature cells of nervous tissue, but lack of morphological signs of dedifferentiation do not support their contribution to reparative neurogenesis in the hippocampus.
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