Abstract
The pathomorphology of the hypothalamo-hypophyseal neurosecretory system and thyroid glands of 150 rats of both sexes was studied during intestinal carcinogenesis induced by 1,2-dimethylhydrazine. The latent period of carcinogenesis was shown to coincide with inhibition of neurosecretion in the paraventricular and supraoptic nuclei and with atrophic changes in the thyroid gland. With the appearance of tumors in the intestine, hypertrophy of the neurons and their nuclei and a decrease in the content of neurosecretory substance were found, accompanied by a tendency toward normalization of the structure of the thyroid gland. The period of spreading cancer was accompanied by increasing hypertrophy of the neurons and a decrease in the content of neurosecretory substance, as well as by marked atrophic changes in the thyroid gland.
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