Abstract
Nowadays the morphological features of esophageal mucosa damage in patients with the gastroesophageal reflux disease (GERD) and the obstructive sleep apnea/hypopnea syndrome (OSAHS) are not completely researched.The objective of the study was to determine the morphological features of esophageal mucosa damage in patients with GERD and OSAHS.143 patients underwent esophagogastroduodenoscopy with biopsy of the lower third of the esophagus and respiratory monitoring. Patients were divided into 4 groups: group 1 – patients with GERD, group 2 – patients with GERD and OSAHS, group 3 – with OSAHS, group 4 – comparison group. Morphological examination with morphometric assessment of epithelium thickness, height of connective tissue papillae, internuclear distances and intercellular spaces was performed.Patients with GERD are characterized by a large thickness of the epithelium, higher connective tissue papillae, wider internuclear spaces in epithelium layers, enlarged intercellular spaces in the epithelium of the esophagus in contrast to the patients of the comparison group. Patients with GERD and OSAHS have a more pronounced epithelium thickness and wider internuclear distances in the prickly layer of the epithelium compared with patients with GERD, the high connective tissue papillae with dilated capillaries and signs of microangiopathy, sclerotic changes in the mucosa of the esophagus are determined.The obtained data show that patients with GERD and OSAHS had more pronounced epithelial disorganization in comparison with patients with GERD without OSAHS.
Highlights
143 patients underwent esophagogastroduodenoscopy with biopsy of the lower third of the esophagus and respiratory monitoring
Patients with gastroesophageal reflux disease (GERD) are characterized by a large thickness of the epithelium, higher connective tissue papillae, wider internuclear spaces in epithelium layers, enlarged intercellular spaces in the epithelium of the esophagus in contrast to the patients of the comparison group
Patients with GERD and obstructive sleep apnea/hypopnea syndrome (OSAHS) have a more pronounced epithelium thickness and wider internuclear distances in the prickly layer of the epithelium compared with patients with GERD, the high connective tissue papillae with dilated capillaries and signs of microangiopathy, sclerotic changes in the mucosa of the esophagus are determined
Summary
143 patients underwent esophagogastroduodenoscopy with biopsy of the lower third of the esophagus and respiratory monitoring. Цель исследования – определение морфологических особенностей поражения слизистой оболочки нижней трети пищевода у пациентов с гастроэзофагеальной рефлюксной болезнью, ассоциированной с синдром обструктивного апноэ/гипопноэ сна. В группе пациентов с ГЭРБ в сочетании с СОАГС при визуальной оценке состояния слизистой воспалительные изменения несколько менее выражены, чем в группе лиц с ГЭРБ, но отмеча ется высокая пролиферативная активность клеток базального слоя эпителия слизистой оболочки пищевода.
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