Morphological features and biological aggressiveness of hepatocellular carcinomas with TERT and TP53 mutations. Preliminary monocentric results on resected patients

Abstract

Introduction. Recently proposed prognostic classifications of hepatocellular carcinoma (HCC) included the mutations of TP53 and CTNNB1. The activation of the promoter gene telomerase reverse transcriptase (TERT) is observed in more than 50% of advanced HCC.