Morphological Feature of Pluronic F127 and Its Application in Burn Treatment.

Abstract

The morphological features of pluronic F127 at various concentrations were investigated and 20% aqueous pluronic F127 solution was chosen for the preparation of biomembrane. The pluronic solution was mixed with appropriate concentration of excipients such as PVA, Povidon S630, PG, Nipagin, Neomycin and Panthenol. The prepared pluronic F127 was thermosensitive, a liquid phase at low temperatures (≤10 °C) but converting into gel at temperatures above 20 °C, and formed stable biomembrane at 37 °C. The neomycin impregnated pluronic membrane suppressed the bacterial growth on agar plate by the sustained release of neomycin. The histological images of skin tissue after applying pluronic gel to burn injured area on rabbit confirmed that the pluronic F127 formulation functioned as a matrix to release drug as well as a biomembrane to protect burn injury. Thus, the formulated pluronic F127 may have a potential for the application of local treatment on burn injury.