Morphological evolution of hnRNPA1 pathological condensates

Abstract

Heterogenous nuclear ribonucleoprotein A1 (hnRNPA1), family member of ubiquitously expressed RNA-binding proteins involved in RNA metabolism, has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) and other neurodegenerative protein misfolding diseases. hnRNPA1 and other RNA-binding proteins (e.g., FUS and TDP-43) are recruited to membrane-less organelles such as stress granules, and are known to readily phase separate in vitro, a property that may play roles not just in their biological functions but also pathologic dysfunctions.