Abstract
An historical review of morphological evidence for immune response to breast cancer is presented. At present it seems as if the closest the morphologist may come to seeing immunity is to see hyperplasia of some elements such as the round cells in tumors or the node changes or the immune system. Evidence now seems overwhelming that histocytosis comes before the good prognosis of less metastatic tumor in the axilla. In fact Black has found greater histiocytic reaction with in situ carcinoma than with invasive carcinoma. That is if the host immunity is great enough invasion may not be permitted even though cancer cells survive in the semiisolated environment of the breast ducts. Excess node tissue showing prominent histocytosis is suggestive of systemic reaction and good prognosis. The work of Black and Leis supports the original suggestion that histocytosis is related to cell-mediated immunity rather than to circulating antibodies.
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