Abstract
BackgroundAmong bones building the axial and appendicular skeleton, the mandible is characterized by unique morphological and functional traits. The aim of the study was to evaluate morphological, densitometric and mechanical properties of mandible in 5-month-old Polish Merino sheep. Using quantitative computed tomography, volumetric bone mineral density (vBMD) and calcium hydroxyapatite density of the cortical bone (CbCa-HA), mean vBMD (MvBMD) and total bone volume were determined. Using computed tomography cross-sectional scans of the mandible, cross-sectional area, second moment of inertia, mean relative wall thickness and cortical index were determined. Three-point bending test was applied to determine mechanical properties. Serum concentration of insulin-like growth factor I (IGF-I) and bone-specific alkaline phosphatase (BAP) was also measured.ResultsAll the investigated morphometric, densitometric and mechanical parameters of the right and left mandibular halves were not significantly different (P > 0.05). There was no correlation of final body weight, MvBMD, CbCa-HA, BAP and IGF-I with all the analyzed parameters of mandible (P > 0.05). However, positive correlations between the other investigated morphometric, densitometric and mechanical parameter of mandible were found (P < 0.05).ConclusionsRelationships between morphological, densitometric and mechanical parameters of the mandible indicate that the elaborated experimental model may serve for further studies on metabolic responses of skeletal system to physiological, nutritional, pharmacological, toxicological and environmental factors.
Highlights
Among bones building the axial and appendicular skeleton, the mandible is characterized by unique morphological and functional traits
Considering that peak bone mass (PBM) in mature mammals is genetically determined in 70–80%, approximately 20–30% of the variation in PBM is determined by environmental factors such as nutrition, physical activity, exposure to sunlight, external temperature and other [4]
The measurements of mean volumetric bone mineral density (vBMD) (MvBMD) and bone volume (Bvol) were performed for the whole mandible and the results obtained reflect MvBMD measured for all the anatomical structures including teeth
Summary
Among bones building the axial and appendicular skeleton, the mandible is characterized by unique morphological and functional traits. The aim of the study was to evaluate morphological, densitometric and mechanical properties of mandible in 5-month-old Polish Merino sheep. Volumetric bone mineral density (vBMD) and calcium hydroxyapatite density of the cortical bone (CbCa-HA), mean vBMD (MvBMD) and total bone volume were determined. Using computed tomography cross-sectional scans of the mandible, cross-sectional area, second moment of inertia, mean relative wall thickness and cortical index were determined. Manipulations of the environmental factors during growth and development period in vertebrates may result in the attainment of higher bone mass of skeletal system expressed by superior bone mineral density, morphological and the Szabelska et al BMC Veterinary Research (2017) 13:12 experimental studies focused on bone metabolism regulation. In this study, morphological, densitometric, and mechanical properties of mandible in 5-month-old Polish Merino male sheep was investigated. The measurements of MvBMD and Bvol were performed for the whole mandible (combined right and left halves) and the results obtained reflect MvBMD measured for all the anatomical structures including teeth
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