Morphological deformities and tissue lesions of some parts of the central nervous system updated with rifampsin Rifampicin in the white mouse embryo Mus musculus

Abstract

The present study aimed to investigating the effects of rifampicin drug to induce morphological malformations and histological defects in some divisions of central nervous system during embryogenesis of swiss albino mice Mus musculus at the level of light microscope. The pregnant female ingested of rifampicin orally as ascending concentrations 150, 250, 350 mg/kg body weight daily, which started at the ih day of pregnancy until delivery of neonate. The result revealed at 150 mg/kg no morphological malformations were observed except some histopatholgical changes in the spinal cord. The ratio of malformes embryos at 250 mg/kg was 14% represented by embryos hypertrophy, Encephalauxe, Embryos cyanosis, and ophthalmoptosis. The histological injuries in the mantle layer of neuro epithelium were vaculation, bleeding, degeneration and necrosis. In addition, decreasing of central canal in the spinal cord appeared. At 350 mg/kg of rifampicin the malformed embryos, were 29%. The morphological defects were enencephalauxe, abdominal teres is with intestinal cenosis appeared lowering of the cranial skull, displacement of otic and straight microcaudale tail appears. Histopathologically many injures appeared as vaculation hypoplasia and necrosis in the mantle layer of neuroepithelium , as well as protrution ofbrain laterally as external brain, in addition to spinal cord damages, compared with control group.