Abstract
The paper studies the influence of Raspol polysaccharide and fosprenil on chicken liver microstructure during vaccination against avian infectious bronchitis. The response to the integrated effects of the vaccine and immunostimulants during this period caused weakly expressed edema in perisinusoid spaces and marked activation of reticuloendothelium cells represented by the increase of Kupffer’s cells. On the 28th day after vaccination, all hepatocytes were distinguished by uniformity of magnitude and shape. They lacked evidence of prior dystrophic changes. Most hepatocytes represented actively synthesizing cells as indicated by dark oxyphilous color of the cytoplasm. RES cells in the walls of sinus capillaries were still numerous, with a large volume of cytoplasm and nucleus. The previous studies refer to the phenomenon in the form of a cluster of lymphoid cells in the perivascular regions of the triad area, mucoid degeneration of vascular walls disappeared. The lumens of biliary passage were well observed, especially in chickens of the first group. The liver of the chicks of the control group after vaccination revealed weakly expressed local vascular disorders and absence of signs of metabolic disorders. Organ parenchyma cells retained structural signs of moderate biosynthetic activity of the cytoplasm and nucleus.
Highlights
World and domestic poultry farming is the fastest growing branch of the agro-industrial complex providing the population with high-quality animal products
Polysaccharides are considered as a promising biocomplex for the creation of new drugs to correct various immune system disorders [18,19,20]
The efficiency of Raspol heteropolysaccharide was determined by immunizing chickens against infectious chicken bronchitis with the SEVAC IBird vaccine
Summary
World and domestic poultry farming is the fastest growing branch of the agro-industrial complex providing the population with high-quality animal products. For more than half a century the poultry industry has been providing the population with high-quality dietary products – poultry meat and egg, the production of which per capita grows from year to year [2]. Under conditions of industrial poultry maintenance at high level of technological stress, secondary immunodeficiency states are recorded in almost 80% of poultry population [13,14,15]. Polysaccharides are considered as a promising biocomplex for the creation of new drugs to correct various immune system disorders [18,19,20]. The search for new immunostimulating drugs of domestic production is an urgent task that requires their study, testing and introduction into veterinary practice
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