Morphological characteristic of premature infants’s kidneys with opened Ductus Arteriosis (by the autopsy).

Abstract

Background. Kidney has protracted nephrogenesis and depend on hemodynamic changes on the highest level in support of natural transition to extrauterine circulation. Fetal communications like Ductus Arteriosus take part in the shunting from the aorta to the pulmonary artery. Increase of this shunting of the blood leads to hyperperfusion with hypoxic changes of some development systems of organs with protracted morphogenesis so like kidneys. Objective. To determine the features of postnatal morphogenesis of the kidneys in premature infants with a gestational age of 25 to 35 weeks on the background of an open ductus arteriosus. Methods. 21 autopsy material premature infant’s kidney which were fixed by 10%-formalin and then were subjected to the standard histological procedures. Slides were stained by hematoxylin and eosin. We used the complex of histological and morphometric methods. There were created 3-demenshional models of kidney’s fragments. We carried out biometrical and statistical analysis. Results. During our research it was determines that the changes of the volume of the functional parenchyma of the kidney and the diameter of the Ductus Arteriosus became in inverse relationship. The wider the duct the smaller the volume of the functional parenchyma because of atrophic and necrotic changes during the late stages of glomerulo- and tubulogenesis. These changes could be distinguished by the quantitative density of development on three germinate layers of the cortex of kidney. Сonclusion. Summing up, it determined the retardation of glomerulogenesis particularly superficial area of the cortex because of the opened Ductus Arteriosus.