MORPHOLOGICAL CHANGES OF THE BLADDER WALL AS A RESULT OF THE ACTION OF EPIRUBICIN

Abstract

Summary. Intravesical administration of chemopreparations is widely used in clinical practice and in experiments. However, there are practically no data on morphological changes during the action of chemotherapy drugs on the mucous membrane of the urinary bladder. Aim: to establish the patterns of morphological changes in the layers of the bladder wall during intravesical administration of epirubicin. Object and methods: the studies use white outbred rats (females, weight 200-250 g). Epirubicin was administered intravesically. Morphological changes of the bladder wall were assessed by light microscopy of fixed preparations of cells stained with hematoxylin and eosin after 2 hours; 3, 7 and 21 days after administration of the epirubicin. The obtained results were analyzed by the method of variational statistics. Results: the obtained data indicate significant disorders on the side of the bladder wall, namely atrophic changes and fibrosis of the submucosal base. Morphological changes indicated circulatory disorders in the vessels of the bladdemucous membrane and the submucosal base, which was accompanied by a significant nonspecific inflammatory reaction. Conclusions: obtained morphological and morphometric data indicate significant changes in the bladder wall of rats under the action of the chemotherapy drug epirubicin.