Morphological Changes of Erythrocytes in Neonates with Perinatal Hypoxia

Abstract

Despite active research on the functional properties of erythrocytes under pathological conditions, this problem is of great importance. One of the causes of fetal and neonatal distress is hypoxia. The consequences of the negative effects of oxygen deficiency on the embryo and fetus can manifest both in utero and after birth, leading to various diseases. The aim of this work is to investigate the effects of acidosis as a marker of perinatal hypoxia on the erythrocyte membrane of newborns in the early neonatal period. The use of an atomic force microscope made it possible to obtain images and cell profiles to assess the morphological and structural characteristics of erythrocytes during hypoxia in children in the early neonatal period. Perinatal hypoxia has been shown to alter erythrocyte morphology and damage membrane structure. The early neonatal period is characterized by changes in the morphological forms and instability of erythrocyte membranes.