Abstract
According to the World Health Organization (WHO), there are about 11 million burns in the world each year, of which 180,000 are fatal. One of the systemic consequences of burn injuries is the so-called burn-associated hypermetabolism, the clinical picture of which includes immunological dysfunction, loss of bone mineral density, endocrine disorders, including thyroid dysfunction. The aim of the study was to establish histological and ultrastructural changes of the thyroid gland of experimental animals 14 days after the simulated thermal trauma of the skin on the background of using first 7 days 0.9 % NaCl solution. At the optical and ultrastructural levels of the study 14 days after thermal skin burn on the background of 0.9 % NaCl solution in the thyroid gland of experimental animals found: follicles – mostly large, overstretched (epithelium flat, with desquamation); cytoplasm of thyrocytes is poor in organelles, part of mitochondria with damaged cristae and enlightened matrix, available electron-dense lysosomes, apical surface smoothed; there is swelling of the capsule and trabeculae, leukocyte infiltration; components of the arterial and venous bed are dilated, there is a deformation of the lumen of blood vessels; hemocapillaries are dilated with numerous erythrocytes and perivascular edema. The detected changes cause a violation of the secretory cycle of thyrocytes, transendothelial metabolism and lead to an imbalance in the production and excretion of thyroid hormones.
Highlights
Despite the modernization of working and living conditions in the XXI century, burn injuries and their longterm consequences remain a pressing problem in modern medicine and create a significant burden on the health care system in Ukraine and around the world
Referring to the data of our previous studies [18], we can trace the morphological changes of thyroid components in 1, 7 and 14 days after thermal burns on the background of the first 7 days of 0.9 % NaCl solution at optical and electron microscopic levels (Table 1)
We see that 1 day after thermal trauma of the skin on the background of the introduction of 0.9 % NaCl solution in the thyroid gland, there are reactive adjuvant-compensatory changes and initial manifestations of destruction
Summary
Despite the modernization of working and living conditions in the XXI century, burn injuries and their longterm consequences remain a pressing problem in modern medicine and create a significant burden on the health care system in Ukraine and around the world. According to the World Health Organization (WHO), about 11 million burns are registered worldwide each year, of which 180,000 are fatal [11, 20]. Due to the body's systemic response, severe skin burns to some extent affect the condition of all human organs. This is confirmed by the fact that during the autopsy of the dead due to severe burns in more than 70 % of cases the direct cause of death is multiple organ failure [9]
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