Abstract
AbstractThe manifestations of intracerebral administration of 3.4 × 10−4 M ouabain were studied in 15‐ and 19‐day‐old chick embryos. No significant changes in the histological structure of the cerebrum were detected in 15‐day‐old embyros. The (Na+–K+)‐ATPase activity was completely suppressed, however, and the spontaneous bioelectric activity was inhibited. In 19‐day‐old embyros distinct swelling and vacuolization of the cellular elements occurred. The (Na+–K+)‐ATPase activity was inhibited to the same extent in 19‐day‐old as in 15‐day‐old cerebral tissue. Ouabain administration resulted in episodes of spike‐and‐wave paroxysmal activity in the EEG of 19‐day‐old embyros, characterized by high amplitude and low frequency discharges. Spontaneous motor activity was inhibited following an initial transient increase. In some cases short episodes of hyperactivity were registered, regularly followed by complete inactivity.
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