Abstract
Gastroenterology Medicine & Research Morphological Aspects of the Pathogenesis of Gallbladder Cholesterosis Morozov IA1* and Khomeriky SG2 1Chumakov Federal Scientific Center for Russian Academy of Sciences, Russia 2Loginov Moscow Clinical Scientific Center, Russia *Corresponding author:Morozov IA, Chumakov Federal Scientific Center for Russian Academy of Sciences, Russia Submission: June 06, 2019;Published: June 17, 2019 DOI: 10.31031/GMR.2019.03.000562 ISSN 2637-7632Volume3 Issue3
Highlights
MethodsNew information is given on the structure of the gallbladder wall and its pathomorphosis in the dynamics of the disease
First messages about cholesterosis gall bubble (GC - gallbladder cholesterosis) appeared still one and a half century ago R Wirhov; A Bottcher
The article presents a new view on the pathogenesis of cholesterosis of the gallbladder, formed on the basis of the morphological study of a large number of gallbladders after cholecystectomy using modern
Summary
New information is given on the structure of the gallbladder wall and its pathomorphosis in the dynamics of the disease. The phenomenon of endocytosis absorption of bile micelles by absorptive epithelial cells and their penetration into their own plate is described for the first time. It is this process that triggers the activation of histiocytes and their transformation into tissue macrophages. For the first time, using immunohistochemistry, it was proved that only macrophages are the phenotypic precursor of foam cells
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