Abstract
Astrocytes are a type of glial cell in the central nervous system responsible for modulating synaptic transmissions, tissue repair, maintaining homeostasis, and are therefore implicated in many neurological diseases. Historically, cortical astrocytes were assumed to be a homogeneous population; however, it has recently been demonstrated that there is both morphological and transcriptome heterogeneity between cortical layers, implying diverse functional capacities and responsibilities. Human astrocytes are also more structurally complex, larger, and have unique subtypes in comparison to the commonly studied rodent astrocytes.
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