Abstract
Thirteen lymphomas consisting of one particular cell type were selected from 135 cases of non-Hodgkin's lymphoma. The lymphoma cells were mainly characterized by irregularly shaped nuclei and faintly stained cytoplasm. The growth pattern of the tumour was diffuse. Immunological phenotyping of suspended cells showed that the tumour cells, irrespective of whether they were isolated from lymphoma tissue or from lymphoma tissue or from peripheral blood of leukaemic cases, bore a dense layer of surface immunoglobulin, lacked cytoplasmic immunoglobulin and receptors for mouse erythrocytes, and expressed both complement-receptor subtypes (i.e., receptors for C3b and C3d) in all but one case. The exceptional case was C3b receptor-positive and C3d receptor-negative. The number of IgG-Fc receptor-bearing cells was usually small. There was a consistently small proportion of non-malignant T cells in the tumour tissue. A comparison of the properties of these lymphomas with those of other types of non-Hodgkin's lymphoma and of non-malignant lymphoid cells, shows that the cells of this type of lymphoma (a) differ morphologically and/or immunologically from the cells of all other known types of non-Hodgkin's lymphoma and (b) resemble centrocytes (cleaved follicular-centre cells) of reactive germinal centres. Thus, this type of lymphoma appears to be an entity that is closely related to, or even derived from, centrocytes.
Highlights
Summary.-Thirteen lymphomas consisting of one particular cell type were selected from 135 cases of non-Hodgkin's lymphoma
(2) Centrocytes small or mediumsized cells with a cleaved or irregularly shaped nucleus; cytoplasm is usually sparse and very weakly basophilic and difficult to recognize in sections (Lennert, 1964)
Those investigators showed that erythrocyte-antibody-complement complexes (EAC) prepared with whole mouse serum (EACmouse) as complement source adhered exclusively to germinal centres
Summary
Summary.-Thirteen lymphomas consisting of one particular cell type were selected from 135 cases of non-Hodgkin's lymphoma. A comparison of the properties of these lymphomas with those of other types of non-Hodgkin's lymphoma and of non-malignant lymphoid cells, shows that the cells of this type of lymphoma (a) differ morphologically and/or immunologically from the cells of all other known types of non-Hodgkin's lymphoma and (b) resemble centrocytes (cleaved follicular-centre cells) of reactive germinal centres. This type of lymphoma appears to be an entity that is closely related to, or even derived from, centrocytes. (2) Centrocytes small or mediumsized cells with a cleaved or irregularly shaped nucleus; cytoplasm is usually sparse and very weakly basophilic and difficult to recognize in sections (Lennert, 1964). We found that Stein et al, 1978a, 1979; Stein & Tolksdorf, GCC bear both complement-receptor sub- 1979)
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