Morphological and immunohistochemistry features of ovaries for women with polycystic ovary syndrome on the background of pelvic inflammatory disease

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathies for women of reproductive age.We studied the morphological and immunohistochemistry features of the structure of the ovaries for women with normal-weight PCOS on the background of inflammatory processes of the genitals.Studies have shown that pelvic inflammatory diseases can play an important role in the manifestation of PCOS for women with normal body weight. Provided that there is inflammation in patients with PCOS occurs lymphocytic and plasmа cells infiltration ovarian stroma, particularly in the cortex, as indicated by positive expression of these markers in plasma cells CD-138 and stasis with expansion of small vessels, which leads to disruption of the microcirculation in ovaries, sclerotic changes and fibrosis. Additionally, when coupled PCOS and inflammation in a pith layer ovaries, including follicular epithelium and stroma significantly impaired expression of estrogen and progesterone receptors, as well as a proliferative marker Ki-67. Thus we can assume that the violations in the formation of hormone-receptor complexes in cells and stromal ovarian follicle is a component of the causes of the processes of folliculogenesis and hormone production in PCOS as a cause of infertility, as well as dysregulation of the hypothalamic - ovaries.Given this important task can be regarded as timely detection of inflammatory processes in women with PCOS, especially in the absence of obesity and timely anti-inflammatory therapy aimed at preventing the development of PCOS symptoms and normalization of ovarian function.