Abstract
Gastroenterology Medicine & Research Morphological and Immunohistochemical Features of the Pancreatic Duct System in Patients with Chronic Pancreatitis Volodymyr G Yareshko, Anton V Yevseiev, Yurii A Mikheiev* Department of Surgery and Minimally Invasive Technologies, Zaporizhia Medical Academy, Ukraine *Corresponding author: Yurii A Mikheiev, PhD, Assistant Professor, Department of Surgery and Minimally Invasive Technologies, SI Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine, Vintera boulevard 20, Zaporizhia, 69096, Ukraine Submission: February 20, 2018; Published: March 21, 2018 DOI: 10.31031/GMR.2018.01.000514 ISSN 2637-7632Volume1 Issue3
Highlights
Chronic pancreatitis is a disease of the pancreas in which recurrent inflammatory episodes result in replacement of pancreatic parenchyma by fibrous connective tissue
A characteristic morphological picture of the chronic pancreatitis in development is a combination of fibrosis with deformation of the duct system due to periductal fibrosis with the expansion of interlobular fibrosis, thickening of intralobular connective tissue strands, as well as considerable crimp and widening of the ducts with retention cysts
Significant structural reorganization of the pancreatic duct system in patients with chronic pancreatitis was observed in 87.5% of cases, in 17.5% of cases the picture was supplemented by phenomena of acinar-ductal metaplasia with the transformation of acinar cells into ductal cells and the formation of small ductal-like structures, the so-called “tubular complexes”
Summary
Chronic pancreatitis is a disease of the pancreas in which recurrent inflammatory episodes result in replacement of pancreatic parenchyma by fibrous connective tissue. With the preservation of secretory activity in conditions of obstruction of the ducts, their compensatory expansion and pancreatic secret infiltrates the surrounding tissue with the formation of edema of the pancreas, followed by intrapancreatic activation of digestive enzymes, in particular trypsinogen, which initiates proteolytic necrobiosis of pancreocytes [4]. In the future, this leads to the formation of “protein caps” pancreatic ducts, due to increased secretion of pancreatic proteins, which are the centers of calcification and lead to the formation of concernments in the ductal pancreatic system [5]. The aim of the present study was to determine morphological and immunohistochemical features of the pancreatic duct system in patients with chronic pancreatitis, who underwent surgery for chronic pancreatitis
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