Abstract
We investigated the effects of postnatal exposure to benz[ a]anthracene (B[ a]A) and benzo[ k]fluoranthene (B[ k]F) on the development of the rat uterus. Neonates were injected on each postnatal days 1–14 with B[ a]A (0.1, 1.0 or 10.0 mg/kg), B[ k]F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 μg/kg) or a vehicle. The rats were killed on day 23. All doses of B[ a]A and B[ k]F induced a reduction of the uterine weight, a reduction of the estrogen receptor α expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (3-day administration of 1.0 μg/kg on postnatal days 20–22) in rats exposed to B[ a]A, B[ k]F and EE was lower than in controls. The study showed that postnatal exposure to B[ a]A and B[ k]F resultes in morphological and functional disorders of the immature rat uterus.
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