Morphological and functional characteristics of tubulointerstitium in IgA-nephropathy

Abstract

Objective. The aim of this study was to investigate the vessels and stroma in renal tubulointerstitium in IgAnephropathy. Design and methods. The coefficient of arterial obstruction was assessed. The laboratory and pathological studies (including immunohistochemistry CD31 and quantitative/semi-quantitative assessment of pathohistopathological changes: atrophy of tubules, local sclerosis, perivascular sclerosis, sclerosed glomeruli, the coefficient of obstruction of the arteries with a diameter greater than 100 microns) were performed. Results. The serum creatinine level inversely correlated with the obstruction coefficient (r = –0,83, p < 0,05), and positively— with perivascular sclerosis (r = 0,64, p < 0,05). There was a statistically significant positive correlation between CD31+ and creatinine (r = 0,60, p < 0,05), and between CD31+ and arterial obstruction coefficient (r = –0,75, p < 0,05). Conclusion. The results suggest that the changes in the vascular structure, and therefore the hemodynamic in renal parenchyma may be responsible for fibrosis in the tubulointerstisium in IgA-nephropathy.