Morphological and electron-microscopic features of the investigated placente in very early previous delivery, complicated premature rupture of membranes

Abstract

The article presents modern phenomena about morphological and electron microscopic features of the studied placentas in very early premature birth, complicated by premature rupture of membranes. These features were studied in different tactics of data management of pregnant women. The objective: study of morphological and electron microscopic features of the studied placentas in very early preterm birth, complicated by PRPO.Materials and methods. All 206 patients were divided into two groups. The main group included 150 pregnant women with PRPO at a gestational age of 22–28 weeks, and the control group included 56 pregnant women with a physiological course of gestation at a period of 22–28 weeks. The main group is divided into 2 groups depending on the duration of waiting tactics and the method of delivery. Group I patients received treatment in accordance with clinical protocols by orders of the Ministry of Health of Ukraine. Pregnant women of group II were offered a tactic that involves prolonging gestation for 5 days (antibiotic therapy, RDS prophylaxis, magnesium therapy, in the presence of streptococcus B – treatment) followed by delivery by cesarean section. All patients with PRPO received antibacterial therapy from the day of hospitalization. Results. The results of the study indicate that no significant differences between the study groups during the study were found. The expression data of progesterone receptors correspond to the results of hormonal research, which also did not reveal significant changes in the study groups, and confirm the theory of finding new provoking factors of PRPO in preterm birth. Conclusions. Thus, it was first demonstrated that the content of progesterone in blood plasma and immunohistochemical expression of progesterone receptors in the placenta on the background of DRPP depends on the gestational age and not on the duration of the anhydrous period.