Abstract
Chick embryo myoblasts have been transformed with a temperature sensitive mutant of Rous Sarcoma virus (RSV ts68). At permissive temperature (36°C) it is shown that transformed myoblasts have lost their ability to form myotubes as well as to express the biochemical markers of myogenic differentiation. Upon a shift to the non-permissive temperature (41°C), the normal program of differentiation is restored; myotubes are formed which express muscle specific proteins.
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