Abstract
Department ofAnatomy, Texas Tech University School ofMedicine, Lubbock, Texas, and Department ofAnatomy, Medical University ofSouth Carolina, Charleston, South CarolinaIncreasing evidence that extracellular macromolecules act as bio-logical stimulants mediating genetic expression in embryonic tissueinteractions (9, 11) has created the need to morphobogically identify,in situ, extracellular macromolecules. Presently, it is generally ac-cepted that the only matrix macromolecule that can be identified bystructural analysis is banded collagen. Complex carbohydrates, gly-cosaminoglycans (GAG), proteoglycans and glycoprotein (GP), havenot been structurally analyzed as collagen to render specific morpho-logic identifications. GAG have been variously
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