Abstract
Purpose: To investigate the morphologic features and identify the risk factors of myopic choroidal neovascularization (CNV).Methods: Eighty-eight eyes of 69 consecutive patients with myopic CNV were included in this study. About 109 eyes of 78 pathologic myopia patients without myopic CNV were randomly selected as the control group. Morphologic features and parameters including scleral thickness (ST), choroidal thickness (CT), posterior staphyloma height and the presence of scleral perforating vessels were obtained and measured by swept-source optical coherence tomography (SS-OCT). Binary logistic regression analysis was performed to identify the risk factors for myopic CNV.Results: Patients with myopic CNV had relatively shorter axial length (P < 0.001) and thicker sclera (P < 0.001) compared to those without. After adjusting age, gender and axial length, thick sclera (OR = 1.333, P < 0.001 per 10-μm increase) and thin choroid (OR = 0.509, P < 0.001 per 10-μm increase) were associated with the presence of myopic CNV. Scleral perforating vessels were detected in the area of myopic CNV in 78.67% of the subjects.Conclusions: A relatively thicker sclera and a thinner choroid are the biological indicators for myopic CNV on SS-OCT. Scleral perforating vessels may also play a pivotal role in the formation of myopic CNV.
Highlights
Myopic choroidal neovascularization (CNV) is a common vision-threatening complication in pathologic myopia (PM) [1]
A myopic CNV was defined as a CNV that was present in eyes with PM [11]
Eighty-eight eyes of 69 patients diagnosed as myopic CNV and 109 eyes of 78 patients served as control group, were included in this study
Summary
Myopic choroidal neovascularization (CNV) is a common vision-threatening complication in pathologic myopia (PM) [1]. The long-term visual prognosis of myopic CNV is extremely poor without treatment. It has been reported that the visual acuity of myopic CNV deteriorated to 20/200 or worse in ∼89 and 96% of eyes in 5 years and 10 years, respectively [3]. Several studies have confirmed that early diagnosis and treatment of myopic CNV predicts a better visual outcome [5, 6]. It is often difficult for patients with PM to notice new occurrences of myopic CNV because of the already impaired vision caused by other pathologies, which will lead to irreversible vision loss [4]
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