Abstract
The morphologic effects of minocycline on the cochlea of guinea pigs were studied by means of histochemistry and electron microscopy. Minocycline is a newly synthesized antibiotic of the tetracycline group and inhibits protein synthesis. The reactions were mainly observed in the cochlear sensory epithelia. Degenerative changes appeared first in the outer hair cells in the upper turn showing vacuolization of endoplasmic reticulum and so on, but nerve endings and inner hair cells showed little change. Stria vascularis, spiral prominence and spiral ligament were almost intact. The protein synthesis in the organ of Corti is stronger than in stria vascularis. This may be the reason why the former was more strongly damaged than the latter. The degeneration of outer hair cells started from the upper turn to the lower. This may indicate that the protein metabolism is more vulnerable in the upper turn.
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