Abstract
Male Sprague-Dawley rats were exposed to dietary levels of 500, 250 and 125 ppm of 3,4′-5-tribromosalicylanilide (TBS) for 1, 3, 5, 7, 9 and 11 weeks. Five hundred ppm of hexachlorophene (HCP) was used for comparison. TBS did not cause any functional or morphologic signs of neurotoxicity. HCP proved to be neurotoxic, causing paralysis of hind legs associated with cerebral and cerebellar edema. A subsequent recovery study comparing animals of the 500 ppm groups of both compounds for 5–8 weeks showed that HCP did not cause irreparable damage. When TBS was given to adult male rats for 3 and 7 weeks at a dietary level of 500 ppm, no adverse effects in the reproductive system were observed. The lack of neurotoxicity of this compound in rats was confirmed.
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