Abstract

To the Editor: Novel combination regimens with immune-checkpoint inhibitors (ICIs) and targeted agents, chemotherapy, and non-ICI immunotherapies have led to unprecedented clinical outcomes in cancer patients,1-3 though there is little research characterizing the morphological patterns of cutaneous toxicities resulting from such regimens. Prior work is largely limited to smaller case series examining specific non-ICI therapies or cancer types2 and does not examine whether cutaneous immune-related adverse events (cirAEs) exhibit the distinct clinical characteristics of their respective anticancer therapies or present as synergistic cutaneous eruptions.

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