Abstract
The advisability of prophylactic regional lymph node extirpation in cases of carcinoma is still controversial. Study of the primary lesions and metastatic lymph node deposits in 23 cases of oral squamous carcinoma shows that the metastatic tumors tend to be better differentiated than their own primaries. A Differentiation Index was devised to assess the degree of differentiation of the carcinoma in each specimen. In addition, it appears that tumor cells may undergo necrosis in the lymph nodes. Although we have no evidence that a metastatic tumor has been totally destroyed in a lymph node, the findings do suggest that the cancerous process is probably slowed down. It is possible that the changes seen may be of the nature of an immune response.
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