Abstract
At the annual meeting of the American Academy of Otolaryngology-Head Neck Surgery in Chicago, Drs Fukuda, Keithley, and Harris, San Diego and La Jolla (Calif), reported that the etiology of endolymphatic hydrops remains unproven. One proposed mechanism is that hydrops occurs following a viral infection of the endolymphatic sac. The authors presented a model to study viral infection of the endolymphatic sac. The model used guinea pigs and a strain of guinea pig–specific cytomegalovirus (CMV). Cytomegalovirus was injected into the endolymphatic sac through a posterior fossa approach. In cases where a live virus was injected into the endolymphatic sac, significant endolymphatic hydrops was found on histologic section. In cases where inactivated CMV was injected into the endolymphatic sac, no hydrops was found. In animals that had been previously sensitized to CMV and had developed antibodies, injection of the live virus resulted in no formation of hydrops. Previous immunization apparently provided
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives of Otolaryngology - Head and Neck Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
