Abstract
In order to elucidate the mechanism of liver giant cell transformation, a morphologic and histochemical study was performed on seven cases of “neonatal hepatitis” in the light microscope, and on one of these also in the electron microscope. The conclusion is reached that the “giant” cells are formed by a growing process of hepatocytes and by budding or fragmentation of their nuclei. In this disease the hepatocytes are incapable of division. They form giant cells which subsequently degenerate. The giant cell transformation is considered as a characteristic change for the mitotic inhibition of the young, growing liver tissue. It may presumably be caused by all agents involving this damage, including nucleoprotein lesion, viruses, serum group incompatibility, drugs' action and hereditary abnormalities.
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