Abstract
Introduction. The pathogenesis of dysbacterioses associated with antibiotic therapy is an urgent medical problem, although some other exogenous and endogenous factors may contribute to the microbiocenosis distortion in the host organism. Purpose. The paper was aimed at studying the morphofunctional state of the stomach and caecum of albino rats after the course of clarithromycin. Material and methods. 30 mature albino male rats weighting 200,0±20,0 g were involved into the experiment. Antibiotic was given to the rodents as a food supplement during their two-meals-a-day feeding. Portions of the stomach and caecum have been studied. Serial paraffin sections were analyzed by using the “Konus” light microscope. Morphometric characteristics of the tissue structures were obtained by the Sigeta X 1 mm/100 Div.x0.01mm stage micrometer. Results and conclusions. In 12 out of 30 subjects, the comparative volume of the caecum was almost twice as less than the volume of the stomach due to a significant enlargement of its fundus, caused by isometric flattening and convergence between its mucous membrane and muscular tunic. In 18 experimental animals, the volumetric capacity of the caecum was twice as larger than the stomach. In contrast, a decrease in the volume of the cecum is associated with a thickening of its wall and increased formation of folds of the mucous membrane that is, probably, caused by insufficient entering of metabolic by-products from the small intestine.
Highlights
The pathogenesis of dysbacterioses associated with antibiotic therapy is an urgent medical problem, some other exogenous and endogenous factors may contribute to the microbiocenosis distortion in the host organism
После завершения эксперимента и после вивисекции, которая осуществлена путем передозировки тиопенталового наркоза (75 мг/кг массы тела животного внутримышечно в верхнюю треть бедра задней лапы) [17, 21] согласно всем нормам и требованиям, предъявляемым к проведению острых опытов над животными, у них проводилось вскрытие полости живота, промывка всего его содержимого физиологическим раствором и погружение их тушек в 10% раствор формалина
Ключові слова: активні форми кисню (АФК); поглинання гідроксильних радикалів; дезоксирибоза; дезінтеграт; деривати пробіотиків
Summary
Chronic combined intoxication increases total NOS activity by 65.9% compared to the control group. The increase in NO production by NOS is the result of a 4-fold increase in iNOS activity, since the activity of cNOS under these conditions does not change significantly. Nitrite reductase-dependent NO production increases by 66.7%, nitrate reductase activity increases by 77.8%. Nitrite content in the testes homogenate grows in 2.17 times. The introduction of nanosized silicon oxide suspension under the conditions of chronic combined intoxication did not statistically significantly change the total NOS activity and cNOS activity compared to the group exposed to chronic intoxication. Nitrate reductase activity decreases in 1.6 times, while nitrite reductase activity decreases in 45%. The activity of arginases lowered in 2.38 times. The nitrite content of the testes cut down by 23.6%
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