Abstract
Objective: To study morphofunctional peculiarities of S. agalactiae-infected placenta. 32 placentas from preterm birth were examined. Morphometric assessment of terminal villi was made with Carl Zeiss microscope using AxioVision software. DNA of intrauterine pathogens was analyzed by a PCR method using domestic test systems. S. agalactiae was found in 9,4 % of the placentas examined. S. agalactiae-infected placentas from preterm birth showed evidence of inflammation and infection processes in membranes, placenta and umbilical cord, signs of chronic placental failure. Morphometric study showed reduced cross-sectional area and perimeter as compared to the mean parameters of infected or non-infected placentas. The specific vascularization features of S.agalactiae-infected placenta are indicative of decreased gas exchange, emergent placental hypoxia and pathogen involvement in the pathogenesis of preterm birth.
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